Old Dog, New Trick: A Tumor-Intrinsic Role for PD-1 in Chemoresistant Tumor Subclones.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36383142.
- Also identified by DOI 10.1158/1078-0432.CCR-22-3022 and PMC identifier 9898080.
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Abstract
Programmed cell death protein 1 (PD-1) is a well-known driver of immunosuppression and lymphocyte-associated disease progression. Increasing evidence suggests a tumor-intrinsic role for PD-1 in promoting chemoresistance via stem-like features. Moving forward, a recent study implies a novel antitumor mechanism for PD-1 inhibition. See related article by Rotolo et al., p. 621.
Medical subject headings
- Programmed Cell Death 1 Receptor
- Lung Neoplasms