The kidney-more than the sum of its cellular parts.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36411017.
- Also identified by DOI 10.1016/j.kint.2022.08.032.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The kidney is a complex organ composed of a plethora of highly specialized cells that talk to each other. The tubuloglomerular feedback is a prototypical example of cell-cell interactions adapting glomerular filtration rate. With the advent of single-cell sequencing techniques, spatial transcriptomics, and bioinformatical cell-cell interaction analyses, we are now able to much better decipher the complex physiology and pathophysiology of these crosstalks, and identify new biomarkers as well as novel treatment options.
Medical subject headings
- Kidney
- Cell Communication