AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36413069.
- Also identified by DOI 10.1093/bioinformatics/btac749 and PMC identifier 9805587.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line interface, a variety of confidence scores and a graphical analysis tool. AlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown. Supplementary note is available at Bioinformatics online.
Medical subject headings
- Software
- Artificial Intelligence