IMMerge: merging imputation data at scale.
Where this comes from
- Record sourced from PubMed, PMID 36413071.
- Also identified by DOI 10.1093/bioinformatics/btac750 and PMC identifier 9805583.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genomic data are often processed in batches and analyzed together to save time. However, it is challenging to combine multiple large VCFs and properly handle imputation quality and missing variants due to the limitations of available tools. To address these concerns, we developed IMMerge, a Python-based tool that takes advantage of multiprocessing to reduce running time. For the first time in a publicly available tool, imputation quality scores are correctly combined with Fisher's z transformation. IMMerge is an open-source project under MIT license. Source code and user manual are available at https://github.com/belowlab/IMMerge.
Medical subject headings
- Genomics
- Genome