Cortical wiring by synapse type-specific control of local protein synthesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36423280.
- Also identified by DOI 10.1126/science.abm7466 and PMC identifier 7618116.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV<sup>+</sup>) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type-specific and synapse type-specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV<sup>+</sup> interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.
Medical subject headings
- Cerebral Cortex
- Interneurons
- Receptor, ErbB-4
- Synapses
- Protein Biosynthesis
- Tuberous Sclerosis Complex 2 Protein