Controlling the crowd with a WNK.

Holt, Liam Joseph; Denes, Lance T · Cell · 2022

editorial · Level V

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Abstract

Volume control is a fundamental challenge for all cells, the mechanisms of which have been long debated. In this issue of Cell, Boyd-Shiwarski et al. find that increased molecular crowding drives condensation of WNK kinase, allowing cells to sense and respond to cell volume loss.

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