[¹⁸F] MFBG PET imaging: biodistribution, pharmacokinetics, and comparison with [¹²³I] MIBG in neural crest tumour patients.

Abstract

Despite its limitations, [¹²³I]MIBG scintigraphy has been the standard for human norepinephrine transporter (hNET) imaging for several decades. Recently, [¹⁸F]MFBG has emerged as a promising PET alternative. This prospective trial aimed to evaluate safety, biodistribution, tumour lesion pharmacokinetics, and lesion targeting of [¹⁸F]MFBG and perform a head-to-head comparison with [¹²³I]MIBG in neural crest tumour patients. Six neural crest tumour patients (4 phaeochromocytoma, 1 paraganglioma, 1 neuroblastoma) with a recent routine clinical [¹²³I]MIBG scintigraphy (interval: - 37-75 days) were included. Adult patients (n = 5) underwent a 30-min dynamic PET, followed by 3 whole-body PET/CT scans at 60, 120, and 180 min after injection of 4 MBq/kg [¹⁸F]MFBG. One minor participant underwent a single whole-body PET/CT at 60 min after administration of 2 MBq/kg [¹⁸F]MFBG. Normal organ uptake (SUV_mean) and lesion uptake (SUV_max; tumour-to-background ratio (TBR)) were measured. Regional distribution volumes (V_T) were estimated using a Logan graphical analysis in up to 6 lesions per patient. A lesion-by-lesion analysis was performed to compare detection ratios (DR), i.e. fraction of detected lesions, between [¹⁸F]MFBG and [¹²³I]MIBG. [¹⁸F]MFBG was safe and well tolerated. Its biodistribution was overall similar to that of [¹²³I]MIBG, with prominent uptake in the salivary glands, liver, left ventricle wall and adrenals, and mainly urinary excretion. In the phaeochromocytoma subgroup, the median V_T was 37.4 mL/cm³ (range: 18.0-144.8) with an excellent correlation between V_T and SUV_mean at all 3 time points (R²: 0.92-0.94). Mean lesion SUV_max and TBR at 1 h after injection were 19.3 ± 10.7 and 23.6 ± 8.4, respectively. All lesions detected with [¹²³I]MIBG were also observed with [¹⁸F]MFBG. The mean DR with [¹²³I]MIBG was significantly lower than with [¹⁸F]MFBG (61.0% ± 26.7% vs. 99.8% ± 0.5% at 1 h; p = 0.043). [¹⁸F]MFBG is a promising hNET imaging agent with favourable imaging characteristics and improved lesion targeting compared with [¹²³I]MIBG scintigraphy. Clinicaltrials.gov : NCT04258592 (Registered: 06 February 2020), EudraCT: 2019-003872-37A.