A large-scale neural network training framework for generalized estimation of single-trial population dynamics.

Keshtkaran, Mohammad Reza; Sedler, Andrew R; Chowdhury, Raeed H; Tandon, Raghav; Basrai, Diya; Nguyen, Sarah L; Sohn, Hansem; Jazayeri, Mehrdad et al. · Nat Methods · 2022

basic_science · Level V

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Abstract

Achieving state-of-the-art performance with deep neural population dynamics models requires extensive hyperparameter tuning for each dataset. AutoLFADS is a model-tuning framework that automatically produces high-performing autoencoding models on data from a variety of brain areas and tasks, without behavioral or task information. We demonstrate its broad applicability on several rhesus macaque datasets: from motor cortex during free-paced reaching, somatosensory cortex during reaching with perturbations, and dorsomedial frontal cortex during a cognitive timing task.

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