A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36459961.
- Also identified by DOI 10.1016/j.stem.2022.11.003.
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Abstract
In this issue of Cell Stem Cell, Porpiglia et al.<sup>1</sup> report on alterations in CD47 and THBS1 expression and function in aged muscle stem cells that disrupt their regeneration capacity. Targeting THBS1-CD47 cross-signaling is sufficient to reverse sarcopenia and restore muscle mass and function in aged mice.
Medical subject headings
- CD47 Antigen
- Myoblasts