Landscape of somatic mutations in aging human heart muscle cells.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 36471785.
- Also identified by DOI 10.1038/s43587-022-00264-2 and PMC identifier 9719721.
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Abstract
Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.
Medical subject headings
- Myocytes, Cardiac
- Aging