dNTP concentrations do not increase in mammalian cells in response to DNA damage.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36476929.
- Also identified by DOI 10.1016/j.cmet.2022.11.002.
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Abstract
A recent publication reported a uniform ∼5- to 6-fold increase in dNTP pools 30 min after exposure to ionizing radiation. Das et al. were not able to reproduce these results. Their data instead agree with earlier publications reporting no increase in dNTP pools in mammalian cells in response to DNA damage.
Medical subject headings
- DNA Damage