Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36476930.
- Also identified by DOI 10.1016/j.cmet.2022.11.006.
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Abstract
The rapid increase of dNTP pools in mammalian cells upon DNA damage has been previously documented. Alterations in protein modifications or interactions can rapidly modulate the activity and protein stability of mammalian RNR, and activation of PRPS1/2-dependent generation of PRPP enhances the production of the indispensable ribose sugar for nucleotide biosynthesis.
Medical subject headings
- DNA Damage