Not so neutral lipids: Metabolic regulation of the pre-metastatic niche.
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- Record sourced from PubMed, PMID 36476931.
- Also identified by DOI 10.1016/j.cmet.2022.11.007 and PMC identifier 10335522.
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Abstract
How primary tumors alter distant tissue sites to facilitate seeding and metastasis remains unclear. In this issue, Gong et al. demonstrate that IL-1β-dependent lipid accumulation in lung mesenchymal cells supports both tumor growth and NK cell dysfunction, facilitating lung metastasis of primary breast tumors.