Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade.
Level V
Where this comes from
- Record sourced from PubMed, PMID 36476933.
- Also identified by DOI 10.1016/j.cmet.2022.11.010.
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Abstract
The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.
Medical subject headings
- Immune Checkpoint Inhibitors
- Neoplasms