Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 36517245.
- Also identified by DOI 10.1136/thorax-2022-219192.
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Abstract
Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma.Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later.Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.
Medical subject headings
- Thymic Stromal Lymphopoietin
- Asthma