A nigro-subthalamo-parabrachial pathway modulates pain-like behaviors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36522327.
- Also identified by DOI 10.1038/s41467-022-35474-0 and PMC identifier 9755217.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The basal ganglia including the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) are involved in pain-related responses, but how they regulate pain processing remains unknown. Here, we identify a pathway, consisting of GABAergic neurons in the SNr (SNr<sup>GABA</sup>) and glutamatergic neurons in the STN (STN<sup>Glu</sup>) and the lateral parabrachial nucleus (LPB<sup>Glu</sup>), that modulates acute and persistent pain states in both male and female mice. The activity of STN neurons was enhanced in acute and persistent pain states. This enhancement was accompanied by hypoactivity in SNr<sup>GABA</sup> neurons and strengthening of the STN-LPB glutamatergic projection. Reversing the dysfunction in the SNr<sup>GABA</sup>-STN<sup>Glu</sup>-LPB<sup>Glu</sup> pathway attenuated activity of LPB<sup>Glu</sup> neurons and mitigated pain-like behaviors. Therefore, the SNr<sup>GABA</sup>-STN<sup>Glu</sup>-LPB<sup>Glu</sup> pathway regulates pathological pain and is a potential target for pain management.
Medical subject headings
- Substantia Nigra
- GABAergic Neurons