Profiling the epigenetic landscape of the antigen receptor repertoire: the missing epi-immunogenomics data.
Level V
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- Record sourced from PubMed, PMID 36522502.
- Also identified by DOI 10.1038/s41592-022-01723-9 and PMC identifier 11058354.
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Abstract
High-resolution sequencing methods that capture the epigenetic landscape within the T cell receptor (TCR) gene loci are pivotal for a fundamental understanding of the epigenetic regulatory mechanisms of the TCR repertoire. In our opinion, filling the gaps in our understanding of the epigenetic mechanisms regulating the TCR repertoire will benefit the development of strategies that can modulate the TCR repertoire composition by leveraging the dynamic nature of epigenetic modifications.
Medical subject headings
- Receptors, Antigen
- Epigenomics