Advances in co-opting anti-depressant drugs in glioma therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36543105.
- Also identified by DOI 10.1016/j.xcrm.2022.100837 and PMC identifier 9797942.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A study by Chryplewicz et al. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compartments in glioma.
Medical subject headings
- Glioma