The gymnastics of intraflagellar transport complexes keeps trains running inside cilia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36563659.
- Also identified by DOI 10.1016/j.cell.2022.12.005.
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Abstract
The assembly and signaling properties of cilia rely on intraflagellar transport (IFT) trains moving proteins into, within, and out of cilia. A flurry of near-atomic models of the multiprotein complexes that make up IFT trains has revealed new conformational changes, which may underlie the switch between anterograde and retrograde intraflagellar transport.
Medical subject headings
- Cilia
- Running