Studying human neural function in vivo at the cellular level: Chasing chimeras?

Vermaercke, Ben; Bonin, Vincent; Vanderhaeghen, Pierre · Cell · 2022

basic_science · Level V

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Abstract

Despite its importance to understanding human brain (dys)function, it has remained challenging to study human neurons in vivo. Recent approaches, using transplantation of human cortical neurons into the rodent brain, offer new prospects for the study of human neural function and disease in vivo, from molecular to circuit levels.

Medical subject headings