Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 36574274.
- Also identified by DOI 10.14309/ajg.0000000000002085 and PMC identifier 9889191.
- Licence recorded as CC BY-NC-ND.
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Abstract
Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility. In this retrospective study, we report the effect of routine inclusion of antimicrobial susceptibility testing and recommendations for eradication therapy with gastric specimens with H. pylori . The use of a recommended treatment regimen based on genetic markers of resistance was associated with an 84% rate of eradication success and 4.4 greater odds of eradication relative to unrecommended treatment. This is the first study describing the use of H. pylori genetic resistance testing as standard of care.
Medical subject headings
- Helicobacter Infections
- Helicobacter pylori