Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36582352.
- Also identified by DOI 10.1016/j.bioactmat.2022.12.009 and PMC identifier 9772805.
- Licence recorded as CC BY-NC-ND.
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Abstract
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on <i>Escherichia coli (E. coli)</i> and <i>Staphylococcus aureus (S. aureus)</i>. It could also promote the proliferation and migration of L929 fibroblasts. <i>In vivo</i> full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group. The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.