Integration of whole transcriptome spatial profiling with protein markers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36593397.
- Also identified by DOI 10.1038/s41587-022-01536-3 and PMC identifier 10272089.
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Abstract
Spatial transcriptomics and proteomics provide complementary information that independently transformed our understanding of complex biological processes. However, experimental integration of these modalities is limited. To overcome this, we developed Spatial PrOtein and Transcriptome Sequencing (SPOTS) for high-throughput simultaneous spatial transcriptomics and protein profiling. Compared with unimodal measurements, SPOTS substantially improves signal resolution and cell clustering and enhances the discovery power in differential gene expression analysis across tissue regions.
Medical subject headings
- Transcriptome
- Gene Expression Profiling