Identification of patient-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cell neoantigens through HLA-unbiased genetic screens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36593398.
- Also identified by DOI 10.1038/s41587-022-01547-0 and PMC identifier 10264241.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cancer neoantigens that arise from tumor mutations are drivers of tumor-specific T cell responses, but identification of T cell-recognized neoantigens in individual patients is challenging. Previous methods have restricted antigen discovery to selected HLA alleles, thereby limiting the breadth of neoantigen repertoires that can be uncovered. Here, we develop a genetic neoantigen screening system that allows sensitive identification of CD4<sup>+</sup> and CD8<sup>+</sup> T cell-recognized neoantigens across patients' complete HLA genotypes.
Medical subject headings
- Antigens, Neoplasm
- Neoplasms