Early immune pressure makes tumors metabolically stronger.
Where this comes from
- Record sourced from PubMed, PMID 36599301.
- Also identified by DOI 10.1016/j.cmet.2022.12.009.
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Abstract
Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that during initial tumorigenesis, T cell-derived IFNγ triggers STAT3 activation and c-Myc-dependent alterations of tumor cell metabolism, which potentiates immune evasion.
Medical subject headings
- Neoplasms