Lymphangioleiomyomatosis (LAM) Cell Atlas.
Where this comes from
- Record sourced from PubMed, PMID 36599466.
- Also identified by DOI 10.1136/thoraxjnl-2022-218772 and PMC identifier 10280816.
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Abstract
Lymphangioleiomyomatosis (LAM) is a rare lung disease of women, causing cystic remodelling of the lung and progressive respiratory failure. The cellular composition, microenvironment and cellular interactions within the LAM lesion remain unclear. To facilitate data sharing and collaborative LAM research, we performed an integrative analysis of single-cell data compiled from lung, uterus and kidney of patients with LAM from three research centres and developed an LAM Cell Atlas (LCA) Web-Portal. The LCA offers a variety of interactive options for investigators to search, visualise and reanalyse comprehensive single-cell multiomics data sets to reveal dysregulated genetic programmes at transcriptomic, epigenomic and cell-cell connectome levels.
Medical subject headings
- Lymphangioleiomyomatosis
- Lung Diseases
- Respiratory Insufficiency
- Lung Neoplasms