Transcriptional programming of pathogenic genes in polycystic kidney disease.
editorial · Level V
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- Record sourced from PubMed, PMID 36603979.
- Also identified by DOI 10.1016/j.kint.2022.10.022.
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Abstract
Transcriptional dysregulation is a prominent contributor to the pathogenesis of autosomal dominant polycystic kidney disease. Lakhia et al. identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst formation. This commentary discusses these findings reported by Lakhia et al. in the broader contexts of transcriptional programming and the identification of potential autosomal dominant polycystic kidney disease therapeutic targets.
Medical subject headings
- Polycystic Kidney, Autosomal Dominant