Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36606251.
- Also identified by DOI 10.1016/j.bioactmat.2022.12.020 and PMC identifier 9804016.
- Licence recorded as CC BY-NC-ND.
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Abstract
Multimodal treatment modalities hold great potential for cancer therapy, thus current efforts are focusing on the development of more effective and practical synergistic therapeutic platforms. Herein, we present a novel <i>trans, trans,trans</i>-[Pt(N<sub>3</sub>)<sub>2</sub>(OH)<sub>2</sub>(py)<sub>2</sub>] (Pt(IV)) prodrug-initiated hydrogel microparticles (M<sub>ICG-Pt</sub>) with indocyanine green (ICG) encapsulation by microfluidics for efficiently synergistic chemo-, photothermal (PTT) and photodynamic therapy (PDT). The employed Pt(IV) could not only serves as an initiator to generate azidyl radical (N<sub>3</sub> <sup>•</sup>) for photo-polymerization of methacrylate gelatin (GelMA) matrix, but also be reduced to high cytotoxic platinum(II) (Pt(II)) species for tumor chemotherapy. The laden ICG with highly photothermal heating ability and intrinsic reactive oxygen species (ROS) productivity endows the M<sub>ICG-Pt</sub> with effective PTT/PDT performances upon near-infrared (NIR) light irradiation. In addition, benefiting from the production of oxygen during the photo-activation process of Pt(IV), the PDT efficacy of ICG-laden M<sub>ICG-Pt</sub> could be further enhanced. Based on these advantages, we have demonstrated that the M<sub>ICG-Pt</sub> could significantly eliminate cancer cells <i>in vitro</i>, and remarkably suppressed the tumor growth <i>in vivo via</i> synergistic chemotherapy, PTT, and PDT. These results indicate that such Pt(IV)-initiated hydrogel microparticles are ideal candidates of multimodal treatment platforms, holding great prospects for cancer therapy.