Sweet splicing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36608648.
- Also identified by DOI 10.1016/j.cell.2022.11.025.
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Abstract
Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction properties, which modifies splicing decisions.
Medical subject headings
- RNA Splicing
- Alternative Splicing