Phage therapy: From biological mechanisms to future directions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36608652.
- Also identified by DOI 10.1016/j.cell.2022.11.017 and PMC identifier 9827498.
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Abstract
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.
Medical subject headings
- Phage Therapy
- Bacteriophages