Regrowing the heart, one TREE at a time.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36608673.
- Also identified by DOI 10.1016/j.stem.2022.12.004.
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Abstract
While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro-regenerative gene expression in injured cardiac tissue of mice and pigs that turn off following repair.
Medical subject headings
- Zebrafish
- Heart