New Antifungals for Vulvovaginal Candidiasis: What Is Their Role?

Sobel, Jack D · Clin Infect Dis · 2023

review · Level V

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Abstract

New antifungals, ibrexafungerp and oteseconazole, are now available for treatment of vulvovaginal candidiasis. Both have novel antimicrobial and pharmacokinetic properties and advantages over fluconazole, although comparative trials have involved only placebo. In the absence of allergy, intolerance, and resistance, it is unclear whether these antifungals will replace fluconazole.

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