PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis.
basic_science · Level V
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- Record sourced from PubMed, PMID 36634117.
- Also identified by DOI 10.1371/journal.pone.0280336 and PMC identifier 9836265.
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Abstract
Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.
Medical subject headings
- Mycobacterium smegmatis
- Bacterial Proteins