Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 36637125.
- Also identified by DOI 10.1093/infdis/jiac498 and PMC identifier 9978315.
- Licence recorded as CC BY-NC-ND.
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Abstract
Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples' HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.
Medical subject headings
- HIV-1
- HIV Infections