Protein structure prediction has reached the single-structure frontier.
Level V
Where this comes from
- Record sourced from PubMed, PMID 36639584.
- Also identified by DOI 10.1038/s41592-022-01760-4 and PMC identifier 9839224.
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Abstract
Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.
Medical subject headings
- Proteins
- Protein Conformation