Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36652912.
- Also identified by DOI 10.1016/j.xcrm.2022.100903 and PMC identifier 9873922.
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Abstract
B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.<sup>1</sup> now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells.
Medical subject headings
- Interferon Type I
- Lupus Erythematosus, Systemic