Size matters in non-canonical inflammasome activation and cell-mediated immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36652913.
- Also identified by DOI 10.1016/j.xcrm.2022.100904 and PMC identifier 9873938.
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Abstract
Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.<sup>1</sup> find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies.
Medical subject headings
- Inflammasomes
- NLR Family, Pyrin Domain-Containing 3 Protein