Is aging a "Retro"spective event?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36669469.
- Also identified by DOI 10.1016/j.cell.2022.12.040.
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Abstract
Reactivation of endogenous retroviruses (ERVs), the relics of ancient infections, has been implicated in a number of disease contexts. In this issue of Cell, Liu et al. show how reactivation of ERVs in old age can induce senescence. This awakening of ERVs is associated with their epigenetic derepression and contributes to age-associated chronic inflammation.
Medical subject headings
- Endogenous Retroviruses
- Aging