Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36685806.
- Also identified by DOI 10.1016/j.bioactmat.2023.01.001 and PMC identifier 9841127.
- Licence recorded as CC BY-NC-ND.
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Abstract
Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, a poly (lactic-<i>co</i>-glycolic acid) (PLGA)-based microneedle patch loaded with magnesium hydride (MgH<sub>2</sub>) (MN-MgH<sub>2</sub>) is manufactured for defeating diabetic wounds. The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH<sub>2</sub> that can generate hydrogen (H<sub>2</sub>) and magnesium ions (Mg<sup>2+</sup>) after reaction with body fluids. The released H<sub>2</sub> reduces the production of ROS, transforming the pathological microenvironment induced by diabetes mellitus. Meanwhile, the released Mg<sup>2+</sup> promotes the polarization of pro-healing M2 macrophages. Consequently, cell proliferation and migration are improved, and angiogenesis and tissue regeneration are enhanced. Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H<sub>2</sub> and Mg<sup>2+</sup> locally and sustainably.