Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 36689730.
- Also identified by DOI 10.14309/ajg.0000000000002137.
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Abstract
This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia. We searched electronic medical records to identify patients with IBD using PPS. Ten of 30 identified patients (33.3%) had colonic dysplasia. Six of them (60%) underwent colectomy for endoscopically unresectable dysplasia. Three (10%) discontinued PPS, each with an apparent benefit. Patients with IBD at 2 institutions who had taken PPS had high rates of colonic dysplasia leading to surgery. Patients who stopped PPS showed improvement in their colitis. PPS may play a causal role in the development of colitis and dysplasia.
Medical subject headings
- Inflammatory Bowel Diseases
- Colitis