Picking a (neuroimmune) fight against fragile regulation of addiction.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36693375.
- Also identified by DOI 10.1016/j.cell.2023.01.003 and PMC identifier 10205172.
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Abstract
T cells and their derived cytokines have been shown to modulate brain function. In this issue of Cell, Zhu, Yan, and colleagues demonstrate that opioid use impacts the crosstalk between the CNS and the peripheral immune system. Regulatory T cell (Treg)-derived IFN-γ signaling translates into synaptic weakening in the nucleus accumbens (NAc) to impart withdrawal-induced behavioral dysfunction.
Medical subject headings
- Nucleus Accumbens
- Signal Transduction
- Opioid-Related Disorders