Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus.

Govind, Anusha; Lazarte, Susana M; Kitchell, Ellen; Chow, Jeremy Y; Estelle, Carolee D; Fixsen, Emma; Helm, Caitlin; Jain, Mamta K et al. · Clin Infect Dis · 2023

case_series · Level IV

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Abstract

In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.

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