Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer.
Where this comes from
- Record sourced from PubMed, PMID 36732329.
- Also identified by DOI 10.1038/s41467-023-36253-1 and PMC identifier 9895058.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.
Medical subject headings
- Neoplasm Recurrence, Local
- Prostatic Neoplasms