Mobility mediates maturation: Synthetic substrates to enhance neural differentiation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36736286.
- Also identified by DOI 10.1016/j.stem.2023.01.001.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al.<sup>1</sup> demonstrate that highly mobile supramolecular scaffolds facilitate long-term hiPSC-derived motor neuron culture, increase maturation-related phenotypes, and recapitulate disease-relevant pathologies.
Medical subject headings
- Induced Pluripotent Stem Cells