An HLA-homozygous haplobank resource to promote safer cell therapies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36736287.
- Also identified by DOI 10.1016/j.stem.2023.01.003.
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Abstract
The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers approximately 40% of the Japanese population and describe quality and safety considerations for manufacturing.
Medical subject headings
- Cell- and Tissue-Based Therapy
- Induced Pluripotent Stem Cells