Extending genetic risk for Alzheimer's disease from host to holobiont.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36750093.
- Also identified by DOI 10.1016/j.cell.2023.01.004.
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Abstract
The gut microbiota is implicated in risk for Alzheimer's disease (AD). A study in Science reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner. This is reversed by administering short-chain fatty acids, suggesting that specific bacterial metabolites increase susceptibility to AD.
Medical subject headings
- Alzheimer Disease
- Gastrointestinal Microbiome