A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36791107.
- Also identified by DOI 10.1073/pnas.2219827120 and PMC identifier 9974460.
- Licence recorded as CC BY-NC-ND.
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Abstract
The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.
Medical subject headings
- Anti-Bacterial Agents
- Macrolides