The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36795458.
- Also identified by DOI 10.7554/eLife.76425 and PMC identifier 9934860.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity. We found that, in rat hippocampal neurons, an intracellular pool of the tetraspanin TSPAN5 promotes exocytosis of AMPA receptors without affecting their internalisation. TSPAN5 mediates this function by interacting with the adaptor protein complex AP4 and Stargazin and possibly using recycling endosomes as a delivery route. This work highlights TSPAN5 as a new adaptor regulating AMPA receptor trafficking.
Medical subject headings
- Receptors, AMPA
- Synapses
- Tetraspanins