Induced epigenetic changes memorized across generations in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36803599.
- Also identified by DOI 10.1016/j.cell.2023.01.023.
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Abstract
Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.
Medical subject headings
- Epigenesis, Genetic
- DNA Methylation