The cost of competency?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36803600.
- Also identified by DOI 10.1016/j.cell.2023.01.010.
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Abstract
Curtailed protein translation ensures stemness and multipotency in embryonic and adult tissue-specific stem cells. In this issue of Cell, a study led by Zhao and colleagues uncovered increased susceptibility of hematopoietic stem cells (HSC) to iron-dependent programmed necrotic cell death (ferroptosis) as a consequence of low protein synthesis.
Medical subject headings
- Hematopoietic Stem Cells
- Protein Biosynthesis